Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization
Identifieur interne : 000906 ( Main/Exploration ); précédent : 000905; suivant : 000907Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization
Auteurs : Judith Eschbach [Allemagne, France] ; Björn Von Einem [Allemagne] ; Kathrin Müller [Allemagne] ; Hanna Bayer [Allemagne] ; Annika Scheffold [Allemagne] ; Bradley E. Morrison [États-Unis] ; K. Lenhard Rudolph [Allemagne] ; Dietmar R. Thal [Allemagne] ; Anke Witting [Allemagne] ; Patrick Weydt [Allemagne] ; Markus Otto [Allemagne] ; Michael Fauler [Allemagne] ; Birgit Liss [Allemagne] ; Pamela J. Mclean [États-Unis] ; Albert R. La Spada [États-Unis] ; Albert C. Ludolph [Allemagne] ; Jochen H. Weishaupt [Allemagne] ; Karin M. Danzer [Allemagne]Source :
- Annals of neurology [ 0364-5134 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Animals, Cells, Cultured, Cerebral Cortex (cytology), Disease Models, Animal, Embryo, Mammalian, Enzyme Inhibitors (pharmacology), Female, Gene Expression Regulation (drug effects), Gene Expression Regulation (genetics), Glioma (pathology), Humans, Macrolides (pharmacology), Male, Mice, Mice, Transgenic, Middle Aged, Neurons (metabolism), PPAR gamma (genetics), PPAR gamma (metabolism), Parkinson Disease (pathology), Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, RNA Polymerase II (genetics), RNA Polymerase II (metabolism), Stilbenes (pharmacology), Substantia Nigra (metabolism), TATA-Box Binding Protein (genetics), TATA-Box Binding Protein (metabolism), Transcription Factors (genetics), Transcription Factors (metabolism), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
- MESH :
- chemical , genetics : PPAR gamma, RNA Polymerase II, TATA-Box Binding Protein, Transcription Factors, alpha-Synuclein.
- chemical , metabolism : PPAR gamma, RNA Polymerase II, TATA-Box Binding Protein, Transcription Factors, alpha-Synuclein.
- chemical , pharmacology : Enzyme Inhibitors, Macrolides, Stilbenes.
- cytology : Cerebral Cortex.
- drug effects : Gene Expression Regulation.
- genetics : Gene Expression Regulation.
- metabolism : Neurons, Substantia Nigra.
- pathology : Glioma, Parkinson Disease.
- Aged, Aged, 80 and over, Animals, Cells, Cultured, Disease Models, Animal, Embryo, Mammalian, Female, Humans, Male, Mice, Mice, Transgenic, Middle Aged, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha.
Abstract
Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD) with accumulating evidence that prefibrillar oligomers and protofibrils are the pathogenic species in PD and related synucleinopathies. Peroxisome proliferator-activated receptor γ (PPARγ) co-activator 1α (PGC-1α), a key regulator of mitochondrial biogenesis and cellular energy metabolism, has recently been associated with the pathophysiology of PD. Despite extensive effort on studying the function of PGC-1α in mitochondria, no studies have addressed whether PGC-1α directly influences oligomerization of α-syn or whether α-syn oligomers impact PGC-1α expression.
In this study, we found that both PGC-1α reference gene (RG-PGC-1α) and the CNS specific PGC-1α (CNS-PGC-1α) are downregulated in human PD brain, in A30P α-syn transgenic animals, and in a cell culture model for α-syn oligomerization. Importantly, down-regulation of both RG-PGC-1α and CNS-PGC-1α in cell culture or neurons from RG-PGC-1α deficient mice leads to a strong induction of α-syn oligomerization and toxicity. In contrast, pharmacological activation or genetic overexpression of RG-PGC-1α reduced α-syn oligomerization and rescued α-syn mediated toxicity.
Based on our results, we propose that PGC-1α downregulation and α-syn oligomerization from a vicious circle thereby influencing and/or potentiating each other. Our data indicate that restoration of PGC-1α is a promising approach for development of effective drugs for the treatment of PD and related synucleinopathies.
Url:
DOI: 10.1002/ana.24294
PubMed: 25363075
PubMed Central: 4293280
Affiliations:
- Allemagne, France, États-Unis
- Alsace (région administrative), Bade-Wurtemberg, Californie, District de Tübingen, Floride, Grand Est
- Strasbourg, Ulm
- Université d'Ulm
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Le document en format XML
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Thal</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Pathology, Ulm University, Helmholtzstrasse 8/1, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, Ulm University, Helmholtzstrasse 8/1, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Witting, Anke" sort="Witting, Anke" uniqKey="Witting A" first="Anke" last="Witting">Anke Witting</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Weydt, Patrick" sort="Weydt, Patrick" uniqKey="Weydt P" first="Patrick" last="Weydt">Patrick Weydt</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Fauler, Michael" sort="Fauler, Michael" uniqKey="Fauler M" first="Michael" last="Fauler">Michael Fauler</name><affiliation wicri:level="4"><nlm:aff id="A6">Institute of Applied Physiology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Applied Physiology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Liss, Birgit" sort="Liss, Birgit" uniqKey="Liss B" first="Birgit" last="Liss">Birgit Liss</name><affiliation wicri:level="4"><nlm:aff id="A6">Institute of Applied Physiology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Applied Physiology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Mclean, Pamela J" sort="Mclean, Pamela J" uniqKey="Mclean P" first="Pamela J." last="Mclean">Pamela J. Mclean</name><affiliation wicri:level="2"><nlm:aff id="A7">Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Weishaupt, Jochen H" sort="Weishaupt, Jochen H" uniqKey="Weishaupt J" first="Jochen H." last="Weishaupt">Jochen H. 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id="A8">Inoviem scientific, 8 allée Gaspard Monge, 67083 Strasbourg, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inoviem scientific, 8 allée Gaspard Monge, 67083 Strasbourg</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Von Einem, Bjorn" sort="Von Einem, Bjorn" uniqKey="Von Einem B" first="Björn" last="Von Einem">Björn Von Einem</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Muller, Kathrin" sort="Muller, Kathrin" uniqKey="Muller K" first="Kathrin" last="Müller">Kathrin Müller</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Bayer, Hanna" sort="Bayer, Hanna" uniqKey="Bayer H" first="Hanna" last="Bayer">Hanna Bayer</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Scheffold, Annika" sort="Scheffold, Annika" uniqKey="Scheffold A" first="Annika" last="Scheffold">Annika Scheffold</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Internal Medicine III, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Morrison, Bradley E" sort="Morrison, Bradley E" uniqKey="Morrison B" first="Bradley E." last="Morrison">Bradley E. Morrison</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rudolph, K Lenhard" sort="Rudolph, K Lenhard" uniqKey="Rudolph K" first="K. Lenhard" last="Rudolph">K. Lenhard Rudolph</name><affiliation wicri:level="1"><nlm:aff id="A4">Leibniz Institute for Age Research, Beutenbergstr. 11, 07745 Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Leibniz Institute for Age Research, Beutenbergstr. 11, 07745 Jena</wicri:regionArea><wicri:noRegion>07745 Jena</wicri:noRegion><wicri:noRegion>07745 Jena</wicri:noRegion><wicri:noRegion>07745 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. Thal</name><affiliation wicri:level="3"><nlm:aff id="A5">Department of Pathology, Ulm University, Helmholtzstrasse 8/1, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, Ulm University, Helmholtzstrasse 8/1, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Witting, Anke" sort="Witting, Anke" uniqKey="Witting A" first="Anke" last="Witting">Anke Witting</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Weydt, Patrick" sort="Weydt, Patrick" uniqKey="Weydt P" first="Patrick" last="Weydt">Patrick Weydt</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Fauler, Michael" sort="Fauler, Michael" uniqKey="Fauler M" first="Michael" last="Fauler">Michael Fauler</name><affiliation wicri:level="4"><nlm:aff id="A6">Institute of Applied Physiology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Applied Physiology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Liss, Birgit" sort="Liss, Birgit" uniqKey="Liss B" first="Birgit" last="Liss">Birgit Liss</name><affiliation wicri:level="4"><nlm:aff id="A6">Institute of Applied Physiology, University of Ulm, Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Applied Physiology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Mclean, Pamela J" sort="Mclean, Pamela J" uniqKey="Mclean P" first="Pamela J." last="Mclean">Pamela J. Mclean</name><affiliation wicri:level="2"><nlm:aff id="A7">Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Weishaupt, Jochen H" sort="Weishaupt, Jochen H" uniqKey="Weishaupt J" first="Jochen H." last="Weishaupt">Jochen H. Weishaupt</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author><author><name sortKey="Danzer, Karin M" sort="Danzer, Karin M" uniqKey="Danzer K" first="Karin M." last="Danzer">Karin M. Danzer</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Cells, Cultured</term><term>Cerebral Cortex (cytology)</term><term>Disease Models, Animal</term><term>Embryo, Mammalian</term><term>Enzyme Inhibitors (pharmacology)</term><term>Female</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (genetics)</term><term>Glioma (pathology)</term><term>Humans</term><term>Macrolides (pharmacology)</term><term>Male</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle Aged</term><term>Neurons (metabolism)</term><term>PPAR gamma (genetics)</term><term>PPAR gamma (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</term><term>RNA Polymerase II (genetics)</term><term>RNA Polymerase II (metabolism)</term><term>Stilbenes (pharmacology)</term><term>Substantia Nigra (metabolism)</term><term>TATA-Box Binding Protein (genetics)</term><term>TATA-Box Binding Protein (metabolism)</term><term>Transcription Factors (genetics)</term><term>Transcription Factors (metabolism)</term><term>alpha-Synuclein (genetics)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>PPAR gamma</term><term>RNA Polymerase II</term><term>TATA-Box Binding Protein</term><term>Transcription Factors</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>PPAR gamma</term><term>RNA Polymerase II</term><term>TATA-Box Binding Protein</term><term>Transcription Factors</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Enzyme Inhibitors</term><term>Macrolides</term><term>Stilbenes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Glioma</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Embryo, Mammalian</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Transgenic</term><term>Middle Aged</term><term>Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson’s disease (PD) with accumulating evidence that prefibrillar oligomers and protofibrils are the pathogenic species in PD and related synucleinopathies. Peroxisome proliferator-activated receptor γ (PPARγ) co-activator 1α (PGC-1α), a key regulator of mitochondrial biogenesis and cellular energy metabolism, has recently been associated with the pathophysiology of PD. Despite extensive effort on studying the function of PGC-1α in mitochondria, no studies have addressed whether PGC-1α directly influences oligomerization of α-syn or whether α-syn oligomers impact PGC-1α expression.</p></sec><sec id="S2"><title>Results</title><p id="P2">In this study, we found that both PGC-1α reference gene (RG-PGC-1α) and the CNS specific PGC-1α (CNS-PGC-1α) are downregulated in human PD brain, in A30P α-syn transgenic animals, and in a cell culture model for α-syn oligomerization. Importantly, down-regulation of both RG-PGC-1α and CNS-PGC-1α in cell culture or neurons from RG-PGC-1α deficient mice leads to a strong induction of α-syn oligomerization and toxicity. In contrast, pharmacological activation or genetic overexpression of RG-PGC-1α reduced α-syn oligomerization and rescued α-syn mediated toxicity.</p></sec><sec id="S3"><title>Interpretation</title><p id="P3">Based on our results, we propose that PGC-1α downregulation and α-syn oligomerization from a vicious circle thereby influencing and/or potentiating each other. Our data indicate that restoration of PGC-1α is a promising approach for development of effective drugs for the treatment of PD and related synucleinopathies.</p></sec></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Tübingen</li><li>Floride</li><li>Grand Est</li></region><settlement><li>Strasbourg</li><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Eschbach, Judith" sort="Eschbach, Judith" uniqKey="Eschbach J" first="Judith" last="Eschbach">Judith Eschbach</name></region><name sortKey="Bayer, Hanna" sort="Bayer, Hanna" uniqKey="Bayer H" first="Hanna" last="Bayer">Hanna Bayer</name><name sortKey="Danzer, Karin M" sort="Danzer, Karin M" uniqKey="Danzer K" first="Karin M." last="Danzer">Karin M. Danzer</name><name sortKey="Fauler, Michael" sort="Fauler, Michael" uniqKey="Fauler M" first="Michael" last="Fauler">Michael Fauler</name><name sortKey="Liss, Birgit" sort="Liss, Birgit" uniqKey="Liss B" first="Birgit" last="Liss">Birgit Liss</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><name sortKey="Muller, Kathrin" sort="Muller, Kathrin" uniqKey="Muller K" first="Kathrin" last="Müller">Kathrin Müller</name><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name><name sortKey="Rudolph, K Lenhard" sort="Rudolph, K Lenhard" uniqKey="Rudolph K" first="K. Lenhard" last="Rudolph">K. Lenhard Rudolph</name><name sortKey="Scheffold, Annika" sort="Scheffold, Annika" uniqKey="Scheffold A" first="Annika" last="Scheffold">Annika Scheffold</name><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. Thal</name><name sortKey="Von Einem, Bjorn" sort="Von Einem, Bjorn" uniqKey="Von Einem B" first="Björn" last="Von Einem">Björn Von Einem</name><name sortKey="Weishaupt, Jochen H" sort="Weishaupt, Jochen H" uniqKey="Weishaupt J" first="Jochen H." last="Weishaupt">Jochen H. Weishaupt</name><name sortKey="Weydt, Patrick" sort="Weydt, Patrick" uniqKey="Weydt P" first="Patrick" last="Weydt">Patrick Weydt</name><name sortKey="Witting, Anke" sort="Witting, Anke" uniqKey="Witting A" first="Anke" last="Witting">Anke Witting</name></country><country name="France"><region name="Grand Est"><name sortKey="Eschbach, Judith" sort="Eschbach, Judith" uniqKey="Eschbach J" first="Judith" last="Eschbach">Judith Eschbach</name></region></country><country name="États-Unis"><region name="Californie"><name sortKey="Morrison, Bradley E" sort="Morrison, Bradley E" uniqKey="Morrison B" first="Bradley E." last="Morrison">Bradley E. Morrison</name></region><name sortKey="La Spada, Albert R" sort="La Spada, Albert R" uniqKey="La Spada A" first="Albert R." last="La Spada">Albert R. La Spada</name><name sortKey="Mclean, Pamela J" sort="Mclean, Pamela J" uniqKey="Mclean P" first="Pamela J." last="Mclean">Pamela J. Mclean</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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